• Adherence to mediterranean diet and the risk of differentiated thyroid cancer in a European cohort: The EPIC study 

      Llaha, Fjorida; Cayssials, Valerie; Farràs, Marta; Agudo, Antonio; Sandström, Maria; Eriksen, Anne Kirstine; Tjønneland, Anne; Boutron-Ruault, Marie-Christine; Laouali, Nasser; Truong, Thérèse; Le Cornet, Charlotte; Katzke, Verena; Schulze, Matthias; Palli, Domenico; Krogh, Vittorio; Signoriello, Simona; Tumino, Rosario; Ricceri, Fulvio; Skeie, Guri; Jensen, Torill Miriam Enget; Chen, Sairah Lai Fa; Lasheras, Cristina; Rodriguez-Barranco, Miguel; Amiano, Pilar; Huerta, José María; Guevara, Marcela; Almquist, Martin; Nilson, Lena Maria; Hennings, Joakim; Papier, Keren; Heath, Alicia; Weiderpass, Elisabete; Rinaldi, Sabina; Zamora-Ros, Raul (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-02)
      Background: The Mediterranean diet (MD) has been proposed as a healthy diet with a potential to lower the incidence of several types of cancer, but there is no data regarding thyroid cancer (TC). We investigated the association between MD adherence, and its components, and the differentiated TC risk within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.<p> <p>Methods: ...
    • Assessment of the EarlyCDT-Lung test as an early biomarker of lung cancer in ever-smokers: A retrospective nested case-control study in two prospective cohorts 

      Wu, Wendy Yi-Ying; Haider, Zahra; Feng, Xiaoshuang; Heath, Alicia K.; Tjønneland, Anne; Agudo, Antonio; Masala, Giovanna; Robbins, Hilary A.; Huerta, María-José; Guevara, Marcela; Schulze, Matthias B.; Rodriguez-Barranco, Miguel; Vineis, Paolo; Tumino, Rosario; Kaaks, Rudolf; Fortner, Renée T.; Sieri, Sabina; Panico, Salvatore; Nøst, Therese Haugdahl; Sandanger, Torkjel M; Braaten, Tonje; Johansson, Mattias; Melin, Beatrice; Johansson, Mikael (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-28)
      The EarlyCDT-Lung test is a blood-based autoantibody assay intended to identify high-risk individuals for low-dose computed tomography lung cancer screening. However, there is a paucity of evidence on the performance of the EarlyCDT-Lung test in ever-smokers. We conducted a nested case-control study within two prospective cohorts to evaluate the risk-discriminatory performance of the EarlyCDT-Lung ...
    • The association between body fatness and mortality among breast cancer survivors: results from a prospective cohort study 

      Bonet, Catalina; Crous-Bou, Marta; Tsilidis, Konstantinos K.; Gunter, Marc J.; Kaaks, Rudolf; Schulze, Matthias B.; Turzanski Fortner, Rénee; Antoniussen, Christian S.; Dahm, Christina C.; Mellemkjær, Lene; Tjønneland, Anne; Amiano, Pilar; Ardanaz, Eva; Colorado-Yohar, Sandra M.; Rodriguez-Barranco, Miguel; Tin Tin, Sandar; Agnoli, Claudia; Masala, Giovanna; Panico, Salvatore; Sacerdote, Carlotta; May, Anne M.; Borch, Kristin Benjaminsen; Rylander, Karin Charlotta Maria; Skeie, Guri; Christakoudi, Sofia; Aune, Dagfinn; Weiderpass, Elisabete; Dossus, Laure; Riboli, Elio; Agudo, Antonio (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-29)
      Evidence linking body fatness to breast cancer (BC) prognosis is limited. While it seems that excess adiposity is associated with poorer BC survival, there is uncertainty over whether weight changes reduce mortality. This study aimed to assess the association between body fatness and weight changes pre- and postdiagnosis and overall mortality and BC-specific mortality among BC survivors. Our study ...
    • Blood cell DNA methylation biomarkers in preclinical malignant pleural mesothelioma: The EPIC prospective cohort 

      Allione, Alessandra; Viberti, Clara; Cotellessa, Ilaria; Catalano, Chiara; Casalone, Elisabetta; Cugliari, Giovanni; Russo, Alessia; Guarrera, Simonetta; Mirabelli, Dario; Sacerdote, Carlotta; Gentile, Marco; Eichelmann, Fabian; Schulze, Matthias B.; Harlid, Sophia; Eriksen, Anne Kirstine; Tjønneland, Anne; Andersson, Martin; Dollé, Martijn E.T.; Van Puyvelde, Heleen; Weiderpass, Elisabete; Rodriguez-Barranco, Miguel; Agudo, Antonio; Heath, Alicia K.; Chirlaque, María-Dolores; Truong, Thérèse; Dragic, Dzevka; Severi, Gianluca; Sieri, Sabina; Sandanger, Torkjel M; Ardanaz, Eva; Vineis, Paolo; Matullo, Giuseppe (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-28)
      Malignant pleural mesothelioma (MPM) is a rare and aggressive cancer mainly caused by asbestos exposure. Specific and sensitive noninvasive biomarkers may facilitate and enhance screening programs for the early detection of cancer. We investigated DNA methylation (DNAm) profiles in MPM prediagnostic blood samples in a case-control study nested in the European Prospective Investigation into Cancer ...
    • Blood polyphenol concentrations and differentiated thyroid carcinoma in women from the European Prospective Investigation into Cancer and Nutrition (EPIC) study 

      Zamora-Ros, Raul; Lujan-Barroso, Leila; Achaintre, David; Franceschi, Silvia; Kyrø, Cecilie; Overvad, Kim; Tjønneland, Anne; Truong, Therese; Lecuyer, Lucie; Boutron-Ruault, Marie Christine; Katzke, Verena; Johnson, Theron S.; Schulze, Matthias B; Trichopoulou, Antonia; Peppa, Eleni; La Vechia, Carlo; Masala, Giovanna; Pala, Valeria; Panico, Salvatore; Tumino, Rosario; Ricceri, Fulvio; Skeie, Guri; Ramón Quirós, J; Rodriguez-Barranco, Miguel; Amiano, Pilar; Chirlaque, María Dolores; Ardanaz, Eva; Almquist, Martin; Hennings, Joakim; Vermeulen, Roel; Wareham, Nicholas J; Tong, Tammy Y.N.; Aune, Dagfinn; Byrnes, Graham; Weiderpass, Elisabete; Scalbert, Augustin; Rinaldi, Sabina; Agudo, Antonio (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-06)
      <p>Background - Polyphenols are natural compounds with anticarcinogenic properties in cellular and animal models, but epidemiological evidence determining the associations of these compounds with thyroid cancer (TC) is lacking. <p>Objectives - The aim of this study was to evaluate the relations between blood concentrations of 36 polyphenols and TC risk in EPIC (the European Prospective Investigation ...
    • Body Size at Different Ages and Risk of 6 Cancers: A Mendelian Randomization and Prospective Cohort Study 

      Mariosa, Daniela; Smith-Byrne, Karl; Richardson, Tom G.; Ferrari, Pietro; Gunter, Marc J.; Papadimitriou, Nikos; Murphy, Neil; Christakoudi, Sofia; Tsilidis, Konstantinos K.; Riboli, Elio; Muller, David; Purdue, Mark P.; Chanock, Stephen J.; Hung, Rayjean J.; Amos, Christopher I.; O'Mara, Tracy A.; Amiano, Pilar; Pasanisi, Fabrizio; Rodriguez-Barranco, Miguel; Krogh, Vittorio; Tjønneland, Anne; Halkjær, Jytte; Perez-Cornago, Aurora; Chirlaque, María-Dolores; Skeie, Guri; Rylander, Charlotta; Borch, Kristin Benjaminsen; Aune, Dagfinn; Heath, Alicia K.; Ward, Heather A.; Schulze, Matthias; Bonet, Catalina; Weiderpass, Elisabete; Davey Smith, George; Brennan, Paul; Johansson, Mattias (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-19)
      It is unclear if body weight in early life affects cancer risk independently of adult body weight. To investigate this question for 6 obesity-related cancers, we performed univariable and multivariable analyses using 1) Mendelian randomization (MR) analysis and 2) longitudinal analyses in prospective cohorts. Both the MR and longitudinal analyses indicated that larger early life body size was ...
    • Dietary intakes of dioxins and polychlorobiphenyls (PCBs) and breast cancer risk in 9 European countries 

      Fiolet, Thibault; Casagrande, Corinne; Nicolas, Geneviève; Horvath, Zsuzsanna; Frenoy, Pauline; Weiderpass, Elisabete; Katzke, Verena; Kaaks, Rudolf; Rodriguez-Barranco, Miguel; Panico, Salvatore; Sacerdote, Carlotta; Manjer, Jonas; Sonestedt, Emily; Grioni, Sara; Agudo, Antonio; Rylander, Charlotta; Nøst, Therese Haugdahl; Skeie, Guri; Tjønneland, Anne; Raaschou-Nielsen, Ole; Ardanaz, Eva; Amiano, Pilar; Dolores Chirlaque López, María; Schulze, Matthias B.; Wennberg, Maria; Harlid, Sophia; Cairat, Manon; Kvaskoff, Marina; Huybrechts, Inge; Romana Mancini, Francesca (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-26)
      Background: Dioxins and polychlorobiphenyls (PCBs) are persistent organic pollutants that have demonstrated endocrine disrupting properties. Several of these chemicals are carcinogenic and positive associations have been suggested with breast cancer risk. In general population, diet represents the main source of exposure.<p><p> Methods: Associations between dietary intake of 17 dioxins and 35 PCBs ...
    • DNA methylome analysis identifies accelerated epigenetic ageing associated with postmenopausal breast cancer susceptibility 

      Ambatipudi, Srikant; Horvath, Steve; Perrier, Flavie; Cuenin, Cyrille; Hernandez-Vargas, Hector; Le Calvez-Kelm, Florence; Durand, Geoffroy; Byrnes, Graham; Ferrari, Pietro; Bouaoun, Liacine; Sklias, Athena; Chajès, Véronique; Overvad, Kim; Severi, Gianluca; Baglietto, Laura; Clavel-Chapelon, Françoise; Kaaks, Rudolf; Barrdahl, Myrto; Boeing, Heiner; Trichopoulou, Antonia; Lagiou, Pagona; Naska, Androniki; Masala, Giovanna; Agnoli, Claudia; Polidoro, Silvia; Tumino, Rosario; Panico, Salvatore; Dollé, Martijn; Peeters, Petra H.M.; Onland-Moret, N. Charlotte; Sandanger, Torkjel M; Nøst, Therese Haugdahl; Weiderpass, Elisabete; Quirós, José Ramón; Agudo, Antonio; Rodriguez-Barranco, Miguel; Huerta Castaño, José María; Barricarte, Aurelio; Fernández, Ander Matheu; Travis, Ruth C.; Vineis, Paolo; Muller, David C.; Riboli, Elio; Gunter, Marc; Romieu, Isabelle; Herceg, Zdenko (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-28)
      Aim of the study: A vast majority of human malignancies are associated with ageing, and age is a strong predictor of cancer risk. Recently, DNA methylation-based marker of ageing, known as ‘epigenetic clock’, has been linked with cancer risk factors. This study aimed to evaluate whether the epigenetic clock is associated with breast cancer risk susceptibility and to identify potential epigenetics-based ...
    • Food biodiversity and total and cause-specific mortality in 9 European countries: An analysis of a prospective cohort study 

      Hanley-Cook, Giles T.; Huybrechts, Inge; Biessy, Carine; Remans, Roseline; Kennedy, Gina; Deschasaux-Tanguy, Mélanie; Murray, Kris A.; Touvier, Mathilde; Skeie, Guri; Kesse-Guyot, Emmanuelle; Argaw, Alemayehu; Casagrande, Corinne; Nicolas, Geneviève; Vineis, Paolo; Millett, Christopher J.; Weiderpass, Elisabete; Ferrari, Pietro; Dahm, Christina C.; Bueno-De-Mesquita, H. Bas; Sandanger, Torkjel M; Ibsen, Daniel B.; Freisling, Heinz; Ramne, Stina; Jannasch, Franziska; van der Schouw, Yvonne T.; Schulze, Matthias B.; Tsilidis, Konstantinos K.; Tjønneland, Anne; Ardanaz, Eva; Bodén, Stina; Cirera, Lluís; Gargano, Giuliana; Halkjær, Jytte; Jakszyn, Paula; Johansson, Ingegerd; Katzke, Verena; Masala, Giovanna; Panico, Salvatore; Rodriguez-Barranco, Miguel; Sacerdote, Carlotta; Srour, Bernard; Tumino, Rosario; Riboli, Elio; Gunter, Marc J.; Jones, Andrew D.; Lachat, Carl (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-18)
      Background<p> <p>Food biodiversity, encompassing the variety of plants, animals, and other organisms consumed as food and drink, has intrinsic potential to underpin diverse, nutritious diets and improve Earth system resilience. Dietary species richness (DSR), which is recommended as a crosscutting measure of food biodiversity, has been positively associated with the micronutrient adequacy of diets ...
    • Food processing and cancer risk in Europe: results from the prospective EPIC cohort study 

      Kliemann, Nathalie; Rauber, Fernanda; Bertazzi Levy, Renata; Viallon, Vivian; Vamos, Eszter P; Cordova, Reynalda; Freisling, Heinz; Casagrande, Corinne; Nicolas, Genevieve; Aune, Dagfinn; Tsilidis, Konstantinos K; Heath, Alicia; Schulze, Matthias B; Jannasch, Franziska; Srour, Bernard; Kaaks, Rudolf; Rodriguez-Barranco, Miguel; Tagliabue, Giovanna; Agudo, Antonio; Panico, Salvatore; Ardanaz, Eva; Chirlaque, María-Dolores; Vineis, Paolo; Tumino, Rosario; Perez-Cornago, Aurora; Andersen, Julie Louise Munk; Tjønneland, Anne; Skeie, Guri; Weiderpass, Elisabete; Monteiro, Carlos Augusto; Gunter, Marc J; Millett, Christopher; Huybrechts, Inge (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-06)
      Background - Food processing has been hypothesised to play a role in cancer development; however, data from large-scale epidemiological studies are scarce. This study investigated the association between dietary intake according to amount of food processing and risk of cancer at 25 anatomical sites using data from the European Prospective Investigation into Cancer and Nutrition (EPIC) study.<p> ...
    • Genetic variation in the ADIPOQ gene, adiponectin concentrations and risk of colorectal cancer: a Mendelian Randomization analysis using data from three large cohort studies 

      Nimptsch, Katharina; Song, Mingyang; Aleksandrova, Krasimira; Katsoulis, Michail; Freisling, Heinz; Jenab, Mazda; Gunter, Marc J.; Tsilidis, Konstantinos K.; Weiderpass, Elisabete; Bueno-De-Mesquita, Hendrik Bastiaan; Chong, Dawn Q.; Jensen, Majken K.; Wu, Chunsen; Overvad, Kim; Kühn, Tilman; Barrdahl, Myrto; Melander, Olle; Jirström, Karin; Peeters, Petra H.; Sieri, Sabina; Panico, Salvatore; Cross, Amanda J.; Riboli, Elio; van Guelpen, Bethany; Myte, Robin; Huerta, José María; Rodriguez-Barranco, Miguel; Quirós, José Ramón; Dorronsoro, Miren; Tjønneland, Anne; Olsen, Anja; Travis, Ruth; Boutron-Ruault, Marie-Christine; Carbonnel, Franck; Severi, Gianluca; Bonet, Catalina; Palli, Domenico; Janke, Jürgen; Lee, Young-Ae; Boeing, Heiner; Giovannucci, Edward L.; Ogino, Shuji; Fuchs, Charles S.; Rimm, Eric; Wu, Kana; Chan, Andrew T.; Pischon, Tobias (Journal article; Manuskript; Tidsskriftartikkel; Peer reviewed; Preprint, 2017-05-26)
      Higher levels of circulating adiponectin have been related to lower risk of colorectal cancer in several prospective cohort studies, but it remains unclear whether this association may be causal. We aimed to improve causal inference in a Mendelian Randomization meta-analysis using nested case–control studies of the European Prospective Investigation into Cancer and Nutrition (EPIC, 623 cases, 623 ...
    • Inflammatory potential of the diet and association with risk of differentiated thyroid cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort 

      Lécuyer, Lucie; Laouali, Nasser; Dossus, Laure; Shivappa, Nitin; Hébert, James R.; Agudo, Antonio; Tjonneland, Anne; Halkjaer, Jytte; Overvad, Kim; Katzke, Verena A.; Le Cornet, Charlotte; Schulze, Matthias B.; Jannasch, Franziska; Palli, Domenico; Agnoli, Claudia; Tumino, Rosario; Dragna, Luca; Iannuzzo, Gabriella; Jensen, Torill Miriam Enget; Brustad, Magritt; Skeie, Guri; Zamora-Ros, Raul; Rodriguez-Barranco, Miguel; Amiano, Pilar; Chirlaque, María-Dolores; Ardanaz, Eva; Almquist, Martin; Sonestedt, Emily; Sandström, Maria; Nilsson, Lena Maria; Weiderpass, Elisabete; Huybrechts, Inge; Rinaldi, Sabina; Boutron-Ruault, Marie-Christine; Truong, Thérèse (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-05-30)
      Purpose - Chronic inflammation is thought to initiate or promote differentiated thyroid cancer (DTC) and previous studies have shown that diet can modulate this inflammatory process. We aimed to evaluate the association of several dietary scores reflecting the inflammatory potential of the diet with DTC risk.<p> <p>Methods - Within the EPIC cohort, 450,063 participants were followed during a mean ...
    • Methodological issues in a prospective study on plasma concentrations of persistent organic pollutants and pancreatic cancer risk within the EPIC cohort 

      Gasull, Magda; Pumarega, José; Kiviranta, Hannu; Rantakokko, Panu; Raaschou-Nielsen, Ole; Bergdahl, Ingvar A.; Sandanger, Torkjel M; Goñi, Fernando; Cirera, Lluís; Donat-Vargas, Carolina; Alguacil, Juan; Iglesias, Mar; Tjønneland, Anne; Overvad, Kim; Mancini, Francesca Romana; Boutron-Ruault, Marie-Christine; Severi, Gianluca; Johnson, Theron; Kühn, Tilman; Trichopoulou, Antonia; Karakatsani, Anna; Peppa, Eleni; Palli, Domenico; Pala, Valeria; Tumino, Rosario; Naccarati, Alessio; Panico, Salvatore; Verschuren, Monique; Vermeulen, Roel; Rylander, Charlotta; Nøst, Therese Haugdahl; Rodriguez-Barranco, Miguel; Molinuevo, Amaia; Chirlaque, Maria-Dolores; Ardanaz, Eva; Sund, Malin; Key, Tim; Ye, Weimin; Jenab, Mazda; Michaud, Dominique; Matullo, Giuseppe; Canzian, Federico; Kaaks, Rudolf; Nieters, Alexandra; Nöthlings, Ute; Jeurnink, Suzanne; Chajes, Veronique; Matejcic, Marco; Gunter, Marc; Aune, Dagfinn; Riboli, Elio; Agudo, Antoni; Gonzalez, Carlos Alberto; Weiderpass, Elisabete; Bueno-de-Mesquita, Hendrik Bastiaan; Duell, Eric J.; Vineis, Paolo; Porta, Miquel (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-23)
      <i>Background</i> - The use of biomarkers of environmental exposure to explore new risk factors for pancreatic cancer presents clinical, logistic, and methodological challenges that are also relevant in research on other complex diseases.<p> <p><i>Objectives</i> - First, to summarize the main design features of a prospective case-control study –nested within the European Prospective Investigation ...
    • Mycotoxin Exposure and Renal Cell Carcinoma Risk: An Association Study in the EPIC European Cohort 

      Claeys, Liesel; De Saeger, Sarah; Scelo, Ghislaine; Biessy, Carine; Casagrande, Corinne; Nicolas, Genevieve; Korenjak, Michael; Fervers, Beatrice; Heath, Alicia K.; Krogh, Vittorio; Luján-Barroso, Leila; Castilla, Jesús; Ljungberg, Börje; Rodriguez-Barranco, Miguel; Ericson, Ulrika; Santiuste, Carmen; Catalano, Alberto; Overvad, Kim; Brustad, Magritt; Gunter, Marc J.; Zavadil, Jiri; De Boevre, Marthe; Huybrechts, Inge (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-30)
      Background: Mycotoxins have been suggested to contribute to a spectrum of adverse health effects in humans, including at low concentrations. The recognition of these food contaminants being carcinogenic, as co-occurring rather than as singularly present, has emerged from recent research. The aim of this study was to assess the potential associations of single and multiple mycotoxin exposures with ...
    • Reproductive and hormonal factors and risk of renal cell carcinoma among women in the European Prospective Investigation into Cancer and Nutrition 

      Clasen, Joanna L.; Mabunda, Rita; Heath, Alicia K.; Kaaks, Rudolf; Katzke, Verena; Schulze, Matthias B.; Birukov, Anna; Tagliabue, Giovanna; Chiodini, Paolo; Tumino, Rosario; Milani, Lorenzo; Braaten, Tonje Bjørndal; Gram, Inger Torhild; Lukic, Marko; Luján-Barroso, Leila; Rodriguez-Barranco, Miguel; Chirlaque, María-Dolores; Ardanaz, Eva; Amiano, Pilar; Manjer, Jonas; Huss, Linnea; Ljungberg, Börje; Travis, Ruth; Smith-Byrne, Karl; Gunter, Marc; Johansson, Matthias; Rinaldi, Sabina; Weiderpass, Elisabete; Riboli, Elio; Cross, Amanda J.; Muller, David C. (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-03)
      Background - Renal cell carcinoma (RCC) is twice as common among men compared with women, and hormonal factors have been suggested to partially explain this difference. There is currently little evidence on the roles of reproductive and hormonal risk factors in RCC aetiology.<p> <p>Materials & Methods - We investigated associations of age at menarche and age at menopause, pregnancy-related factors, ...
    • Timing of eating across ten European countries - Results from the European Prospective Investigation into Cancer and Nutrition (EPIC) calibration study 

      Huseinovic, Ena; Winkvist, Anna; Freisling, Heinz; Slimani, Nadia; Boeing, Heiner; Buckland, Genevieve; Schwingshackl, Lukas; Olsen, Anja; Tjønneland, Anne; Stepien, Magdalena; Boutron-Ruault, Marie-Christine; Mancini, Francesca; Artaud, Fanny; Kühn, Tilman; Katzke, Verena; Trichopoulou, Antonia; Naska, Androniki; Orfanos, Philippos; Tumino, Rosario; Masala, Giovanna; Krogh, Vittorio; Santucci De Magistris, Maria; Ocké, Marga C.; Brustad, Magritt; Enget Jensen, Torill; Skeie, Guri; Rodriguez-Barranco, Miguel; Huerta, José María; Ardanaz, Eva; Quirós, José Ramón; Jakszyn, Paula; Sonestedt, Emily; Ericson, Ulrika; Wennberg, Maria; Key, Timothy J.; Aune, Dagfinn; Riboli, Elio; Weiderpass, Elisabete; Berteus Forslund, Helene (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-17)
      <p><i>Objective</i>: To examine timing of eating across ten European countries.</p> <p><i>Design</i>: Cross-sectional analysis of the European Prospective Investigation into Cancer and Nutrition (EPIC) calibration study using standardized 24 h diet recalls collected during 1995–2000. Eleven predefined food consumption occasions were assessed during the recall interview. We present time of consumption ...